Renal compromise in a patient with Wegener’s granulomatosis: clinical case and literature review
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Keywords

Renal impairment
Adverse events
Wegener’s granulomatosis
Renal replacement therapy.

How to Cite

1.
Fabris Vargas JL, Jaramillo G, Torres R, Rosselli C, Olivares O. Renal compromise in a patient with Wegener’s granulomatosis: clinical case and literature review. Rev. Colomb. Nefrol. [Internet]. 2017 Feb. 20 [cited 2021 Dec. 7];4(1):99-111. Available from: http://www.revistanefrologia.org/index.php/rcn/article/view/234

Abstract

Wegener’s granulomatosis (WG) is characterized by small vessel vasculitis that affects the upper respiratory tract, lungs and kidneys. Renal involvement may occur between 40 and 100% of cases. The disease varies from asymptomatic to fulminant rapidly progressive glomerulonephritis forms, leading to terminal renal failure in days.

Methodology
We present a case of a patient diagnosed with WG in the Hospital de San José in Bogotá, Colombia, and a literature review focused on renal involvement. Literature search was conducted in the following databases: PubMEed, LILAC, SciELO and Cochrane. Articles in english and spanish were selected and no restriction date was made, but at least 70% of selected references were published after 2010.

Conclusions
Renal involvement in patients with WG is common and can be lethal. A high percent may even require renal replacement therapy, although patients can return to normal renal function. Factors associated with return to normal renal function are unclear, but it depends on early therapy and high doses of immunomodulators. Rituximab has shown greater effectiveness and fewer side effects than conventional treatments, so it’s a valid therapeutic option for the management of patients with WG and renal involvement.

https://doi.org/10.22265/acnef.4.1.234
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