Biomarcadores en fluídos biológicos y su potencial uso como indicadores de nefritis lúpica en individuos con lupus eritematoso sistémico

  • Lisandro Pacheco Lugo Universidad Simón Bolívar, Barranquilla, Colombia
  • Yirys Díaz Olmos Universidad Simón Bolívar, Barranquilla, Colombia
  • Gustavo Aroca Martínez Universidad Simón Bolívar, Barranquilla, Colombia

Resumen

La nefritis lúpica es una de las manifestaciones más severas del lupus eritematoso sistémico. El compromiso renal en pacientes con lupus eritematoso sistémico es un causal importante de morbilidad y mortalidad. La patogénesis de la nefritis lúpica involucra múltiples factores, entre los que se incluyen predisposición genética, regulación epigenética e interacción ambiental. Los parámetros clínicos convencionales tales como eliminación de creatinina, proteinuria, sedimentos urinarios, anticuerpos anti-ADN de doble cadena y niveles del complemento no son lo suficientemente sensibles o específicos para detectar actividad de la enfermedad.
En las últimas décadas, las técnicas basadas en “Ómicas” (proteómica, genómica, transcriptómica, metabolómica) han sido utilizadas de manera extensa para la búsqueda de biomarcadores, las cuales han permitido descubrir una amplia variedad de variantes que son asociadas con lupus eritematoso sistémico y nefritis lúpica.
Esos descubrimientos han expandido nuestro entendimiento de las bases moleculares de la enfermedad y han sido muy importantes para la identificación de potenciales blancos terapéuticos para predicción de la enfermedad y tratamiento temprano. En esta revisión, resumimos algunos de los estudios recientes enfocados en la identificación de biomarcadores asociados a nefritis lúpica en diversos fluidos biológicos.

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Biografía del autor/a

Lisandro Pacheco Lugo, Universidad Simón Bolívar, Barranquilla, Colombia
Investigador Grupo de Nefrología, Facultad de Medicina, Universidad Simón Bolívar, Barranquilla, Colombia
Yirys Díaz Olmos, Universidad Simón Bolívar, Barranquilla, Colombia
Estudiante de Maestría, Universidad Simón Bolívar, Barranquilla, Colombia
Gustavo Aroca Martínez, Universidad Simón Bolívar, Barranquilla, Colombia
Estudiante de Maestría, Universidad Simón Bolívar, Barranquilla, Colombia

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