Analysis of post-transplant renal graft survival
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Keywords

Disease-free survival
Graft rejection/Epidemiology
Graft rejection
Medical Care Statistics

How to Cite

1.
Dávila FA, Luna RD, Pardo Rey DA. Analysis of post-transplant renal graft survival. Rev. Colomb. Nefrol. [Internet]. 2016 Jan. 9 [cited 2021 Dec. 7];2(2):96-101. Available from: https://www.revistanefrologia.org/index.php/rcn/article/view/204

Abstract

Introduction: Post renal transplant patients have a survival mean lower than the general population. This survival decreases more when it is related to graft failure. This paper aims to identify the contribution of risk factors to graft loss.

Materials and methods: Retrospective Cohort Study of post renal transplantation; the general characteristics of the patients were described; the RR (Risk ratio) was calculated for the risk of graft lost (p <0.05) and survival differences were explored through Kapplan Meier diagrams.

Results: 164 cases were analyzed; the median age was 48 years; weight was 68 kg, creatinine clearance a year from transplant was 57.17 mg/dl; overall graft survival at 5 years was 88.4%, and 92.1% for patients. Risk ratio (RR) of graft loss in those who experienced rejection in the first year was 3.86; (p = 0.002). Significant differences in graft survival at five years in patients older than fifty years vs patients younger than fifty years (96.8 vs 83.2%, respectively) were found. The extent of these differences was the same after 70 months (5.8 years).

Conclusions: The contribution of pre-transplant risk factors to graft loss were identified, having age as the single associated factor, as this is lower in patients older than 50 years. Given these results, a closer monitoring of patients younger than 50 years is recommended until the fifth year after transplantation.

https://doi.org/10.22265/acnef.2.2.204
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