Membranoproliferative glomerulonephritis due to essential mixed cryoglobulinemic vasculitis
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Membranoproliferative glomerulonephritis
complement pathway alternative
systemic vasculitis
nephrotic syndrome
acute kidney injury.

How to Cite

Cañas Osorio JM, García García Álvaro, Rodelo Ceballos J, Arias LF. Membranoproliferative glomerulonephritis due to essential mixed cryoglobulinemic vasculitis. Rev. Colomb. Nefrol. [Internet]. 2016 Nov. 18 [cited 2022 May 19];3(2):124-31. Available from:


We present the case of a 48 years old man with no known comorbidities, who sought for medical atention at San Vicente Fundación Universitary Hospital, complaining of a two month history with progressive dyspnea, generalized edema and macroscopic urinary changes, in whom hypertension, progressive kidney function decline, azotemia, nephrotic syndrome (9 g/24 h proteinuria), active urinary sediment, hypocomplementemia (C3 and C4) and cryoglobulinemia were found on ancillary tests. The kidney ultrasonography did not reveal findings suggestive of chronicity and the electrophoresis/immunifixation tests showed a polyclonal hypergammaglobulinemic pattern (without light chains). On the kidney biopsy an immunocomplex mediated membranoproliferative glomerulonephritis pattern of lesion was found, with rheumatic and neoplastic etiologies being ruled out. The patient was diagnosed with idiopatic immunocomplex mediated membranoproliferative glomerulonephritis due to mixed essential cryoglobulinemic vasculitis and immunosuppressive therapy (for remission induction) was started, with resolution of edemas, recovery of kidney function and a progressive decline in proteinuria from 9gr/dl to less than 1.8gr/dl on follow up evaluation.
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