Clinical and Histologic Characteristic of Renal Parenchymal Diseases in a Renal Biopsy Sample since 2002 to 2017 in Caldas - Colombia
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Kidney diseases

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García Herrera HG, Restrepo Valencia CA, Buitrago Villa CA. Clinical and Histologic Characteristic of Renal Parenchymal Diseases in a Renal Biopsy Sample since 2002 to 2017 in Caldas - Colombia. Rev. Colomb. Nefrol. [Internet]. 2018 Aug. 9 [cited 2021 Dec. 7];5(2):107-1. Available from:


Background: Renal syndromes are clinical and laboratory manifestations that indicate functional and morphological alterations. Renal biopsy is essential in the diagnosis of kidney parenchymal diseases and provides valuable information in incidence, distribution and possible control of the disease.

Objective: To describe the clinical and histological characteristics of renal parenchymal diseases in a sample of renal biopsies.

Methods: We included 269 patients older than 14 years who underwent renal biopsy by any method. They were classified by indication of biopsy and by type of primary or secondary kidney injury.

Results: The average age was 57,04 (SD ± 17,17 years). The median creatinine was 1,51 mg / dL (RIC=1,22 - 2,01) and the GFR for CKDEPI was 42,7 mil/minute (RIC=30,6 - 56,5). The most frequent renal biopsy indications were unexplained chronic kidney disease (46,8 %), non-nephrotic proteinuria (20,1 %), nephritic syndrome (8,2 %), acute kidney injury (7,1 %), glomerular hematuria with change in the pattern (7,1 %), nephrotic syndrome (6,7 %) and unexplained low glomerular filtration for age (4,1 %). The most frequent finding were IgA nephropathy (20,9 %), hypertensive nephropathy (19 %), focal and segmental glomerulosclerosis (11,6 %), tubulointerstitial nephritis (9,7 %), diabetic glomerulopathy (8,6 %), membranoproliferative glomerulonephritis (3,7 %), extracapillary proliferative glomerulonephritis (3,4 %).

Conclusions: IgA nephropathy and focal segmental glomerulosclerosis are the main primary glomerulopathies. Hypertensive nephropathy and tubulointerstitial nephritis are the main secondary etiologies.
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