Characterization of thyroid dysfunction in adults with chronic renal disease in dialysis
PDF (Español (España))
HTML (Español (España))


Thyroid gland
kidney failure
glomerular filtration rate

How to Cite

Chavez WF, Ariza García AM, Ramos Clason EC. Characterization of thyroid dysfunction in adults with chronic renal disease in dialysis. Rev. Colomb. Nefrol. [Internet]. 2018 Aug. 9 [cited 2021 Dec. 7];5(2):156-65. Available from:


Background: There is a clear relationship between thyroid dysfunction and chronic kidney disease (CKD), which is evidenced by the increase in the prevalence of primary hypothyroidism when the glomerular filtration rate decreases

Objectives: Characterize adult patients with thyroid dysfunction and chronic kidney disease on dialysis therapy.

Methods: An observational, descriptive, cross-sectional study was carried out that characterized and collected laboratory reports of patients >18 years of age with CKD in dialysis therapy of a renal unit of the city of Cartagena/Bolívar with TSH control in 2016.

Results: 350 patients with TSH registry were included, with a median age of 59 years and 49.1% were women. The main cause and comorbidity of CKD was hypertension in 36.3% and hyperpatioidism in 56% respectively. In relation to thyroid dysfunction, 25.4% of the population had TSH levels> 4.5 ?IU/mL, of which 5.7% had TSH levels> 10 ?IU/mL (hypothyroidism).

Conclusions: The prevalence of thyroid dysfunction was higher than in the general population, however additional studies with measurement of FT4 are necessary to achieve an adequate categorization.
PDF (Español (España))
HTML (Español (España))


1. Lopera-Medina MM. La enfermedad renal crónica en Colombia: necesidades en salud y respuesta del Sistema General de Seguridad Social en Salud. Rev Gerenc Polít Salud. 2016;15(30):212-233.

2. Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab. 2012;16(2):204-213.

3. Khatiwada S, Kc R, Gautam S, Lamsal M, Baral N. Thyroid dysfunction and dyslipidemia in chronic kidney disease patients. BMC Endocr Disord. 2015;15:65.

4. Mohamedali M, Reddy Maddika S, Vyas A, Iyer V, Cheriyath P. Thyroid disorders and chronic kidney disease. Int J Nephrol. 2014;2014:520281.

5. Kulkarni DP, Holley JL. Thyroid function test in end-stage renal disease. Semin Dial. 2014;27:552-555.

6. Rhee CM. The interaction between thyroid and kidney disease: an overview of the evidence. Curr Opin Endocrinol Diabetes Obes. 2016;23(5):407-415.

7. Rhee CM, Kalantar-Zadeh K, Streja E, Carrero J-J, Ma JZ, Lu JL, et al. The relationship between thyroid function and estimated glomerular filtration rate in patients with chronic kidney disease. Nephrol Dial Transplant. 2014;30(2):282-287.

8. Rhee CM, Alexander EK, Bhan I, Brunelli SM. Hypothyroidism and mortality among dialysis patients. Clin J Am Soc Nephrol. 2013;8:593-6019.

9. Rhee CM, Ravel VA, Streja E, Mehrotra R, Kim S, Wang J, et al. Thyroid functional disease and mortality in a national peritoneal dialysis cohort. J Clin Endocrinol Metab. 2016;101(11):4054-4061.

10. Rhee CM, Kim S, Gillen DL, Oztan T, Wang J, Mehrotra R, et al. Association of thyroid functional disease with mortality in a national cohort of incident hemodialysis patients. J Clin Endocrinol Metab. 2015;100(4):1386-1395.

11. Tatar E, Kircelli F, Ok E. The contribution of thyroid dysfunction on cardiovascular disease in patients with chronic kidney disease. Atherosclerosis. 2013;227(1):26-31.

12. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260-272.

13. Martínez FL, Ordóñez IE, García DL. Deficiencias en el tratamiento de pacientes diabéticos que terminaron en enfermedad renal crónica. Acta Med Colomb. 2007;32(2):57-67.

14. Abraham G, Arun K, Gopalakrishnan N, Renuka S, Pahari DK, Deshpande P, et al. Management of Hypertension in Chronic Kidney Disease: Consensus Statement by an Expert Panel of Indian Nephrologists. J Assoc Physicians India. 2017;65(2):6-22.

15. Ministerio de Salud y Protección Social. Situación de la enfermedad renal crónica, hipertensión arterial y diabetes mellitus, 2015 [Internet]. Bogotá: Ministerio de Salud y Protección Social; 2015. Disponible en:

16. Mendelssohn DC, Ethier J, Elder SJ, Saran R, Port FK, Pisoni RL. Haemodialysis vascular access problems in Canada: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS II). Nephrol Dial Transplant. 2005;21(3):721-728.

17. Douthat WG, Castellano M, Berenguer L, Guzmán MA, Arteaga Jd, Chiurchiu CR, et al. Elevada prevalencia de hiperparatiroidismo secundario en pacientes con enfermedad renal crónica en diálisis en Argentina. Nefrología (Madr.). 2013;33(5):657-666.

18. Nakhoul G, Simon JF. Anemia of chronic kidney disease: Treat it, but not too aggressively. Cleve Clin J Med. 2016;83(8):613-624.

19. Pineda J, Galofré JC, Toni M, Anda E. Hipotiroidismo. Medicine. 2016; 12:722-730.

20. Chandra A. Prevalence of hypothyroidism in patients with chronic kidney disease: a cross-sectional study from North India. Kid ney Res Clin Pract. 2016;35(3):165-168.

21. Bajaj S, Purwar N, Gupta A, Gupta P, Srivastava A. Prevalence of hypothyroidism in nondiabetic chronic kidney disease and effect of thyroxine replacement on estimated glomerular filtration rate. Indian J Nephrol. 2017;27(2):104-107.

22. Sanai T, Okamura K, Rikitake S, Fukuda M, Onozawa K, Sanematsu M, et al. The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients. Clin Nephrol. 2017;87(5):237-244.

23. Lo JC, Chertow GM, Go AS, Hsu C-Y. Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int. 2005;67(3):1047-1052.

24. Ng YY, Wu SC, Da Lin H, Hu FH, Hou CC, Chou YY, et al. Prevalence of clinical and subclinical thyroid disease in a peritoneal dialysis population. Perit Dial Int. 2012;32(1):86-93.

25. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;22(12):1200-35.

26. Bensenor IM, Olmos RD, Lotufo PA. Hypothyroidism in the elderly: diagnosis and management. Clin Interv Aging. 2012;7:97-111.

27. Ashmaik A, Gabra HM, Elzein AOM, Shrif NEMA, Hassan EE. Assessment of serum levels of calcium and phosphorous in Sudanese patients with hypothyroidism. Asian J Biomed Pharm Sci. 2013;3(25):21-26.

28. Shivaleela MB, Poornima RT, Jayaprakash Murthy DS. Serum calcium and phosphorus levels in thyroid dysfunction. Indian journal of fundamental and applied life sciences. 2012;2(2):179-183.

29. Suneel B, Nagendra DR, Aparna RR, Balakrishna D, Naidu JN. Mineral Status in Thyroid Disorder (Hypo & Hyper). Int J Appl Biol Pharm. 2011;2(4):423-429.

30. Bellorin-Font E, Ambrosoni P, Carlini RG, Carvalho AB, Correa-Rotter R, Cueto-Manzano A, et al. Clinical practice guidelines for the prevention, diagnosis, evaluation and treatment of mineral and bone disorders in chronic kidney disease (CKD-MBD) in adults. Nefrologia. 2013;33(1):1-28.

31. Carrero J, Qureshi A, Axelsson J, Yilmaz M, Rehnmark S, Witt M, et al. Clinical and biochemical implications of low thyroid hormone levels (total nd free forms) in euthyroid patients with chronic kidney disease. J Intern Med. 2007;262(6):690-701.

32. Zoccali C, Mallamaci F, Tripepi G, Cutrupi S, Pizzini P. Low triiodothyronine and survival in end-stage renal disease. Kidney international. 2006;70(3):523-8.

33. Lin HJ, Lin CC, Lin HM, Chen HJ, Lin CC, Chang CT, et al. Hypothyroidism is associated with all?cause mortality in a national cohort of chronic hemodialysis patients. Nephrology (Carlton). 2017;23(6): 559-564.

34. Shin DH, Lee MJ, Lee HS, Oh HJ, Ko KI, Kim CH, et al. Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism. Thyroid. 2013;23(6):654-61.

35. Rhee CM. The interaction between thyroid and kidney disease: an overview of the evidence. Curr Opin Endocrinol Diabetes Obes. 2016;23(5):407-15.
No national or foreign publication may partially or totally reproduce or translate Revista Colombiana de Nefrología articles or abstracts without prior written permission from the journal’s Editorial Board.


Download data is not yet available.