Abstract
Calciphylaxis is one of the less common complications of Chronic Advanced Kidney Disease, especially in renal replacement therapy, the exact pathophysiology of its appearance is unknown, but it is believed that it is due to an alteration in bone-mineral metabolism.We describe a clinical case of a patient with chronic kidney disease, who presented as a serious complication calciphylaxis, reaching this diagnosis thanks to the characteristic images of this pathology taken from the bank of the Hospital’s imaging service.
In conclusion, calciphylaxis, despite being a pathology difficult to find nowadays due to better control of bone-mineral metabolism, should be considered especially in those patients with rapid progression of renal disease and presence of suppurative calcified lesions in extremities.
References
1. Pérez J, Vargas J, Echeverri J, Rodríguez P, Pulido J. Calcifilaxis y enfermedad renal crónica. Acta Médica Colomb. 2011;36(3):149-52. 2. Sckell C, Shupp E, Britez M, Rossi J. Calcifilaxis –una entidad trascendente en Nefrología y Medicina Interna–. Tendencias en Med. 2015;10(14):74-8.
3. Nigwekar S, Zhao S, Wenger J, Hymes J, Maddux F, Thadhani R, et al. A Nationally Representative Study of Calcific Uremic Arteriolopathy Risk Factors. J Am Soc Nephrol [Internet]. 2016;27(11):3421-9.https://doi.org/10.1681/ASN.2015091065
4. Hayashi M, Takamatsu I, Kanno Y, Yoshida T, Abe T, Sato Y. A case-control study of calciphylaxis in Japanese end-stage renal disease patients. Nephrol Dial Transplant. 2012;27(4):1580-4. https://doi.org/10.1093/ndt/gfr658
5. Magro C, Simman R, Jackson S. Calciphylaxis: A review. J Am Col Certif Wound Spec [Internet]. Elsevier Inc; 2010;2(4):66-72. https://doi.org/10.1016/j.jcws.2011.03.001
6. Bleibel W, Hazar B, Herman R. A Case Report Comparing Various Radiological Tests in the Diagnosis of Calcific Uremic Arteriolopathy. Am J Kidney Dis. 2006;48(4):659-61. https://doi.org/10.1053/j.ajkd.2006.05.031
7. Cucchiari D, Torregrosa J. Calcifilaxis en pacientes con enfermedad renal crónica?: una enfermedad todavía desconcertante y potencialmente mortal. Rev la Soc española Nefrol. 2018;38(6):579-86. https://doi.org/10.1093/ndt/gfv438
8. Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, et al. Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry. Nephrol Dial Transplant. 2017;32(1):126-32. https://doi.org/10.1093/ndt/gfv438
9. Fernández M, Morales E, Gutierrez E, Polanco N, Hernández E, Mérida E. Calcifilaxis: más allá de CKD-MBD. Rev la Soc española Nefrol. 2017;37(5):501-7. https://doi.org/10.1016/j.nefro.2017.02.006
10. Rodríguez-Villarreal I, Callejas R, Sánchez M, Laso N, Gallar P, Ortega O, et al. Calcifilaxis o arteriolopatía urémica calcificante: combinación de tratamientos. NefroPlus. 2010;3(3):39-44. https://doi.org/10.3265/NefroPlus.pre2010.Jul.10502
11. Polaina M, Sánchez M, Biechy M, Liebana A. Calcifilaxis. Semin la Fund Española Reumatol. 2009;10(4):124-7.
3. Nigwekar S, Zhao S, Wenger J, Hymes J, Maddux F, Thadhani R, et al. A Nationally Representative Study of Calcific Uremic Arteriolopathy Risk Factors. J Am Soc Nephrol [Internet]. 2016;27(11):3421-9.https://doi.org/10.1681/ASN.2015091065
4. Hayashi M, Takamatsu I, Kanno Y, Yoshida T, Abe T, Sato Y. A case-control study of calciphylaxis in Japanese end-stage renal disease patients. Nephrol Dial Transplant. 2012;27(4):1580-4. https://doi.org/10.1093/ndt/gfr658
5. Magro C, Simman R, Jackson S. Calciphylaxis: A review. J Am Col Certif Wound Spec [Internet]. Elsevier Inc; 2010;2(4):66-72. https://doi.org/10.1016/j.jcws.2011.03.001
6. Bleibel W, Hazar B, Herman R. A Case Report Comparing Various Radiological Tests in the Diagnosis of Calcific Uremic Arteriolopathy. Am J Kidney Dis. 2006;48(4):659-61. https://doi.org/10.1053/j.ajkd.2006.05.031
7. Cucchiari D, Torregrosa J. Calcifilaxis en pacientes con enfermedad renal crónica?: una enfermedad todavía desconcertante y potencialmente mortal. Rev la Soc española Nefrol. 2018;38(6):579-86. https://doi.org/10.1093/ndt/gfv438
8. Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, et al. Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry. Nephrol Dial Transplant. 2017;32(1):126-32. https://doi.org/10.1093/ndt/gfv438
9. Fernández M, Morales E, Gutierrez E, Polanco N, Hernández E, Mérida E. Calcifilaxis: más allá de CKD-MBD. Rev la Soc española Nefrol. 2017;37(5):501-7. https://doi.org/10.1016/j.nefro.2017.02.006
10. Rodríguez-Villarreal I, Callejas R, Sánchez M, Laso N, Gallar P, Ortega O, et al. Calcifilaxis o arteriolopatía urémica calcificante: combinación de tratamientos. NefroPlus. 2010;3(3):39-44. https://doi.org/10.3265/NefroPlus.pre2010.Jul.10502
11. Polaina M, Sánchez M, Biechy M, Liebana A. Calcifilaxis. Semin la Fund Española Reumatol. 2009;10(4):124-7.
No national or foreign publication may partially or totally reproduce or translate Revista Colombiana de Nefrología articles or abstracts without prior written permission from the journal’s Editorial Board.