Contamination of preservation fluid in kidney transplant. Report and literature review
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Keywords

organ preservation, kidney transplant, chronic kidney disease.

How to Cite

1.
Garrido DI, Arias L, Valarezo S, Osorio W, Huertas J. Contamination of preservation fluid in kidney transplant. Report and literature review. Rev. Colomb. Nefrol. [Internet]. 2019 Jun. 19 [cited 2022 Jan. 27];6(2):52-158. Available from: http://www.revistanefrologia.org/index.php/rcn/article/view/343

Abstract

Chronic kidney disease is a public health problem with high morbidity and mortality, kidney transplantation being one of the current therapeutic alternatives. In12 published works concerning the contamination of the preservation fluid in kidney transplant, four case reports, and eight prevalence studies. The prevalence of preservation liquid contamination for any microorganism ranged from
17.43% to 59.72%, while for those limited to the Candida sp report, the frequency varied from 1.69% to 8.57%. In the case reports, all were associated with Candida infection, with renal artery arteritis and graft loss as the most frequent complications. In our institution, of a total of 59 transplant patients, at least one microorganism was isolated in 20 cases (28.17%). Preservation fluid contamination is a frequent phenomenon in kidney transplantation. However, since no publications are describing the complications associated with infection by other microorganisms, we could say that contamination by Candida sp, despite not having a high prevalence, it is clinically the most relevant.

https://doi.org/10.22265/acnef.6.2.343
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References

Arocha-Rodulfo JI, Amair-Maini P. Metformina en enfermedad renal diabética: estado actual. Rev. Colomb. Nefrol. 2017;4(2):188-192. http://dx.doi.org/10.22265/acnef.4.2.255

Gonzalez-Bedat MC, Rosa-Diez G, Ferreiro A. El Registro Latinoamericano de Diálisis y Trasplante Renal: la importancia del desarrollo de los registros nacionales en Latinoamérica. Nefrol Latinoam. 2017;14(1):12-21. https://doi.org/10.1016/j.nefrol.2016.12.002

Yoo KD, Kim CT, Kim MH, Noh J, Kim G, Kim H, et al. Superior outcomes of kidney transplantation compared with dialysis: An optimal matched analysis of a national population-based cohort study between 2005 and 2008 in Korea. Medicine (Baltimore) 2016;95(33):e4352. https://doi.org/10.1097/MD.0000000000004352

Rao VK. Long term results and complications of renal transplantation: Observations in the third decade. Indian J Nephrol. 2001;11:155-159.

Rodríguez BF, Natário AS, Vizinho RS, Jorge CM, Weigert AL, Martinho A, et al. Candida species contamination of preservation fluid- outcome of renal transplantation in 6 patients. Transplant Proc. 2013;45(6):2215-9. https://doi.org/10.1016/j.transproceed.2013.03.024

Bertrand D, Pallet N, Sartorius A, Zahar JR, Soussan RS, Lortholary O, et al. Clinical and microbial impact of screening kidney allograft preservative solution for bacterial contamination with high-sensitivity methods. Transpl Int. 2013;26(8):795-9. https://doi.org/10.1111/tri.12130

Veroux M, Corona D, Scriffignano V, Caglià P, Gagliano M, Giuffrida G, et al. Contamination of preservation fluid in kidney transplantation: single-center analysis. Transplant Proc 2010;42(4):1043-5. https://doi.org/10.1016/j.transproceed.2010.03.041

Canaud G, Timsit MO, Zuber J, Bougnoux ME, Méjean A, Thervet E, et al. Early conservative intervention for candida contamination of preservative fluid without allograft nephrectomy. Nephrol Dial Transplant. 2009;24(4):1325-7. https://doi.org/10.1093/ndt/gfn622

Matignon M, Botterel F, Audard V, Dunogue B, Dahan K, Lang P, et al. Outcome of renal transplantation in eight patients with Candida sp. contamination of preservation fluid. Am J Transplant. 2008;8(3):697-700. https://doi.org/10.1111/j.1600-6143.2007.02112.x

Wakelin SJ, Casey J, Robertson A, Friend P, Jaques BC, Yorke H, et al. The incidence and importance of bacterial contaminants of cadaveric renal perfusion fluid. Transpl Int. 2005;17(11):680-6. https://doi.org/10.1007/s00147-004-0792-6

Ranghino A, Diena D, Simonato F,Messina M, Burdese M, Piraina V, et al. Clinical impact of bacterial contamination of perfusion fluid in kidney transplantation. Springerplus. 2016;5(7):1-6. https://doi.org/10.1186 s40064-015-1658-3

Schiavelli R, Ajzenszlos M, Maiolo E, Rojas-Campoverde N, Sabbatiello R, Di Tullio D, et al. Contamination of Preservation Fluid in Cadaveric Renal Transplantation. Transplantation 2018;102:s643. https://doi.org/10.1097/01.tp.0000543562.60464.45

Dębska-Ślizień A, Chrobak Ł, Bzoma B, Perkowska A, Zadrożny D, Chamienia A, et al. Candida arteritis in kidney transplant recipients: case report and review of the literature. Transpl Infect Dis. 2015;17(3):449-55. https://doi.org/10.1111/tid.12388

Mai H, Champion L, Ouali N, Hertig A, Peraldi MN, Glotz D, et al. Candida albicans arteritis transmitted by conservative liquid after renal transplantation: a report of four cases and review of the literature. Transplantation. 2006;82(9):1163-7. https://doi.org/10.1097/01.tp.0000239188.27153.23

Gari-Toussaint M, Ngoc LH, Gigante M, Sendid B, Cassuto-Viguier E, Bertout S, et al. Kidney transplant and Candida albicans arteritis. The importance of analysing the transplant conservation liquid. Presse Med. 2004; 33(13):866-868.

Spees EK, Light JA, Oakes DD, Reinmuth B. Experiences with cadáver renal allograft contamination before transplantation. Br J Surg. 1982;69(8): 482-485. https://doi.org/10.1002/bjs.1800690819

Escalante-Cobo JL, del Rio-Gallegos F. Preservación de órganos. Med Intensiva 2009:33(6);282-292.

Verrecchia F, Tacheau C, Wagner EF, Mauviel A. A central role for the JNK pathway in mediating the antagonistic activity of pro- inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression. J Biol Chem. 2003;278(3):1585-93. https://doi.org/10.1074/jbc.M206927200

Lee ST, Kim JA, Jang SY, Kim DK, Kim JW, Ki CS. A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. Heart Vessels. 2008;23(2):144-8. https://doi.org/10.1007/s00380-007-1027-4

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